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Abstract: Injuries to the skin are extensively costly to the health care
system. When caused by metabolic and vascular compromise, these
injuries are even more foreboding for patients. They can result in
chronic inflammation, reduced mobility, and chronic pain. Materials
and Methods. Twenty patients were selected from the author’s patient
population at the West Boca Center for Wound Healing for a retrospective
cohort study. Patients underwent a run-in period of 2 weeks, where
standard of care was used to clear the wound of bioburden. A dehydrated,
human amniotic membrane (dHAM; WoundEx Membrane, Skye
Biologics, Inc, El Segundo, CA) was applied at weeks 1 (2 weeks post
run-in), 3, and 5, if necessary. Wound measurements and photographs
were performed weekly. Data were collected through a standard form in
each patient’s medical record to improve reliability and reproducibility.
The data extraction was performed by the author and to reduce bias.
Reduction of bias was performed by selecting patients whose wounds
already were established and in temporal sequence. Results. In this
review of 20 patients treated with the dHAM, the author was able to
effectively close all wounds in approximately 9.9 weeks (69.3 days). A
linear relationship was discovered between wound size in cm2 and days
to closure. Diabetic foot ulcers closed on average in 11.8 weeks (82.6
days) and venous leg ulcers in 9.2 weeks (64.4 days). No adverse
events were noted secondary to the dHAM application, which shows
this is a safe and effective treatment option. As of the date of this publication,
there is no recurrence of the ulcerations noted. Conclusion.
The use of this particular dHAM allograft effectively closed diabetic
foot ulcerations in 82.6 days and median wound closure in 69.3 days.
This poses as an advantageous clinical benefit in the scope of treatment
of lower extremity wounds.
Key words: amniotic allografts, wound regeneration, advanced wound
care, diabetes, healing rate, remodeling
Wounds Epub 2017 January 23
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